"Cell-mediated immune response diagnostics for the early prediction of sepsis"

Problem

Sepsis is a potentially deadly condition that occurs when the immune system detects and responds to a new pathogen in the bloodstream, triggering a chain reaction of auto-immune damage. Worldwide, sepsis affects approximately 27 million people each year, up to 30% of mortality rate. Sepsis often occurs as a co-morbidity in patients with other serious conditions; it is especially problematic in older or infirm adults. The cost of Sepsis worldwide is estimated at €32 billion/year.

 The timing of the diagnosis and treatments are key to controlling the disease – the earlier Sepsis is confirmed, the greater chance for patient survival and recovery. Current detection methods to confirm Sepsis take between 6 hours and two days. Methodology ranges from the use of serum biomarkers (results come in 6-12 hours), to testing for the pathogen (results come in 1-2 days). 

Solution

 

A novel first-in-class in vitro cellular immunoassay that identifies sepsis after the first-hour of bloodstream infection.

We have developed a patented method and kit (with disposable) to identify immune activity biomarkers, that is 3x more sensitive than the current biomarker competitor (PCT) and provides a 10x faster diagnosis than pathogen identification.

Our biomarker appears after the first hour of infection, long before PCT can detect the presence of Sepsis. This will allow healthcare professionals to begin accurate treatment earlier – reducing the severity of the disease and decreasing the number of antibiotics or other drugs necessary for treatment.

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Invitro disposable device: Lateral flow strip + Reactives

Reader device: simplifies the process

Characteristics

Predictive results

Easy workflow

Results < 2 Hours

Room temp storage

3x More sensitivity than current market biomarker (PCT)

Team

Enrique Hernández

CEO & CSO

Erica Plata

CMO (Medical)

Joan Vieyra

CTO

Eduard Guerrero

COO & CFO

Partners

Story

Loop Diagnostics started in MOEBIO’s dHEALTH BCN program a disruptive talent initiative powered by Biocat and inspired by Stanford Biodesign During dHealth hundreds of interviews were performed to patients, ed physicians, internists, nurses, hospital managers and other related KOL to study and verify the enormous impact of sepsis and the unmet medical need of a rapid accurate diagnostic test for sepsis. Since then the aim of Loop Diagnostics is to built a point of care medical device to solve this need.

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Funding and collaborators

The first rapid test that identifies bacteria in blood before they progress in
sepsis: Development and clinical validation of a device to identify cases of sepsis
through totally innovative technology and biomarkers that allow
the identification of the presence of sepsis, in very early stages of the
disease and in a much faster way than current methods. 

Line of R&D projects in SMEs:  04/18/SO/0017.

 

News

SeptiLoop in the program #Starthealth run by Tecnocampus

We are pleased to announce the participation of product #SeptiLoop in the new program #starthealth run by Tecnocampus The program will provide us with market-specific mentoring and professional support to further validate our business model, access financing, and get...

Chapter 5 of the Loop Story: the results 👩‍💻

In the first months after the constitution of the company, our focus was to develop the business model and market access plan for a sepsis diagnostic device. This was done thanks to incubator programs, but in the meantime, we had been recruiting patients for a year to...

We have been featured in the PlantaDoce digital newspaper!

Follow the link to read about the interview done to our COO Eduard Guerrero Aiguabella where he talks about the current situation of the company and our open investment round....

Chapter 1 of the Loop Story: the beginning 🚀

The Story of Loop Diagnostics begins in 2017 with Enrique, our CEO, when he finished his PhD in immunology and infectious diseases in Hospital de la Paz (Madrid) and his postdoc in Hospital de Bellvitge (Barcelona) where he studied the immune system of septic...

Chapter 2 of the Loop Story: the idea

The clinical need for a sepsis diagnostic tool was identified from the earliest stages of the company. So, what technologies are being developed to solve this need? A lot of effort is being put into biomarker identification for the detection of sepsis in the Emergency...

Cross4Health funding to finish our MVP

@loopdx , a project we launch, has developed together with @ucomillas  and industrial designer Raoul Jansen #SeptiBell, a diagnostic device that aids ER physicians make better clinical decisions and optimize #sepsis management. @Cross4Health  

SeptiLoop in the program #Starthealth run by Tecnocampus

We are pleased to announce the participation of product #SeptiLoop in the new program #starthealth run by Tecnocampus The program will provide us with market-specific mentoring and professional support to further validate our business model, access financing, and get...

Cross4Health funding to finish our MVP

@loopdx , a project we launch, has developed together with @ucomillas  and industrial designer Raoul Jansen #SeptiBell, a diagnostic device that aids ER physicians make better clinical decisions and optimize #sepsis management. @Cross4Health  

Chapter 2 of the Loop Story: the idea

The clinical need for a sepsis diagnostic tool was identified from the earliest stages of the company. So, what technologies are being developed to solve this need? A lot of effort is being put into biomarker identification for the detection of sepsis in the Emergency...

Chapter 1 of the Loop Story: the beginning 🚀

The Story of Loop Diagnostics begins in 2017 with Enrique, our CEO, when he finished his PhD in immunology and infectious diseases in Hospital de la Paz (Madrid) and his postdoc in Hospital de Bellvitge (Barcelona) where he studied the immune system of septic...

We have been featured in the PlantaDoce digital newspaper!

Follow the link to read about the interview done to our COO Eduard Guerrero Aiguabella where he talks about the current situation of the company and our open investment round....

Chapter 5 of the Loop Story: the results 👩‍💻

In the first months after the constitution of the company, our focus was to develop the business model and market access plan for a sepsis diagnostic device. This was done thanks to incubator programs, but in the meantime, we had been recruiting patients for a year to...

Contact Us

Loop Dx emails:

Enrique Hernández, enrique@loopdx.com

Eduard Guerrero, eduard@loopdx.com

Joan Vieyra, joan@loopdx.com

Loop Dx offices:

Bioinformatic office: C. Santa Maria 4, 42001, Soria, Spain.

Cowork StartUB: C. Pau Gargallo, 30 (entrada Pascual i Vila), 08028, Barcelona, Spain.

Storage State2: C. de Santander, 45, 08020 Barcelona, Spain.

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